{"id":9273,"date":"2023-02-16T10:00:32","date_gmt":"2023-02-16T10:00:32","guid":{"rendered":"https:\/\/demo.wockhardt.com\/?page_id=9273"},"modified":"2023-06-30T06:52:44","modified_gmt":"2023-06-30T06:52:44","slug":"wck-5222","status":"publish","type":"page","link":"https:\/\/www.wockhardt.com\/about-us\/research-and-development\/new-drug-discovery\/publications\/wck-5222\/","title":{"rendered":"WCK 5222"},"content":{"rendered":"\t\t
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In vitro activity of cefepime\/zidebactam and cefepime\/taniborbactam against aztreonam\/avibactam-resistant NDM-like-producing Escherichia coli clinical isolates<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong> Christophe Le Terrier , Patrice Nordmann, Mustafa Sadek, Laurent Poirel<\/p>

Journal Name –\u00a0<\/strong>Journal of Antimicrobial Chemotherapy<\/p>

Citation\u00a0<\/b>\u00a0–\u00a0<\/strong>2023 May; 78(5): 1191\u20131194<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Successful Use of Cefepime-Zidebactam (WCK 5222) as a Salvage Therapy for the Treatment of Disseminated Extensively Drug-Resistant New Delhi Metallo-\u03b2-Lactamase-Producing Pseudomonas aeruginosa Infection in an Adult Patient with Acute T-Cell Leukemia<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong> Praveen Kumar Tirlangi, Bala Saheb Wanve, Ramakanth Reddy Dubbudu, Boorgula Sushma Yadav, L. Siva Kumar, Anand Gupta, Racha Amarthya Sree, Hari Priya Reddy Challa, P. Naveen Reddy<\/p>

Journal Name –\u00a0<\/strong>Antimicrobial Agents and Chemotherapy<\/p>

Citation\u00a0<\/b>\u00a0–\u00a0<\/strong>Ahead of Print\u00a0\u00a0<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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In Vitro Activity of Two Cefepime-Based Novel Combinations, Cefepime\/Taniborbactam and Cefepime\/Zidebactam, against Carbapenemase-Expressing Enterobacterales Collected in India<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong> Bakthavatchalam YD, Elangovan D, Jaganathan SV, Subburaju N, Shankar A, Manokaran Y, J S, Devi R, Baveja S, Devi S, S J, Bhattacharya S, S M R, Yesudhason B, Shetty V, Mutreja A, Manesh A, Varghese GM, Marwick CA, Parcell BJ, Gilbert IH, Veeraraghavan B<\/p>

Journal Name –\u00a0<\/strong>Microbiology spectrum<\/p>

Citation\u00a0<\/b>\u00a0–<\/strong> 2023 Feb 27;11(2):e0492522<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Activity of cefiderocol, imipenem\/relebactam, cefepime\/taniborbactam and cefepime\/zidebactam against ceftolozane\/tazobactam- and ceftazidime\/avibactam-resistant Pseudomonas aeruginosa<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong> Cristina Lasarte-Monterrubio, Pablo Arturo Fraile-Ribot, Juan Carlos V\u00e1zquez-Ucha, Gabriel Cabot, Paula Guijarro-S\u00e1nchez, Isaac Alonso-Garc\u00eda, Soraya Rumbo-Feal, F\u00e1tima Gal\u00e1n-S\u00e1nchez, Alejandro Beceiro, Jorge Arca-Su\u00e1rez, Antonio Oliver, Germ\u00e1n Bou<\/p>

Journal Name –\u00a0<\/strong>Journal of Antimicrobial Chemotherapy<\/p>

Citation\u00a0<\/b>\u00a0–\u00a0<\/strong>2022, AOP, dkac241\u00a0<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Antimicrobial activity of cefepime\/zidebactam (WCK 5222), a \u03b2-lactam\/\u03b2-lactam enhancer combination, against clinical isolates of Gram-negative bacteria collected worldwide (2018\u201319)<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong>Helio S Sader, Rodrigo E Mendes, Leonard R Duncan, Cecilia G Carvalhaes, Mariana Castanheria<\/p>

Journal Name –\u00a0<\/strong>Journal of Antimicrobial Chemotherapy<\/p>

Citation\u00a0<\/b>\u00a0–<\/strong>2022, 77(10),2642-2649\u00a0<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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In Vitro Activity of New \u03b2-Lactam\u2013\u03b2-Lactamase Inhibitor Combinations and Comparators against Clinical Isolates of Gram-Negative Bacilli: Results from the China Antimicrobial Surveillance Network (CHINET) in 2019<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong>Yan Guo, Renru Han, Bo Jiang, Li Ding, Fengzhen Yang, Beijia Zheng, Yang Yang, Shi Wu, Dandan Yin, Demei Zhu, Fupin Hu<\/p>

Journal Name –\u00a0<\/strong>Microbiology Spectrum<\/p>

Citation\u00a0<\/b>\u00a0–<\/strong>2022, AOP, e0185422\u00a0<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Molecular Characterization of WCK 5222 (Cefepime\/Zidebactam)-Resistant Mutants Developed from a Carbapenem-ResistantPseudomonas aeruginosaClinical Isolate<\/span><\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong>Xiaolei Pan, Xinrui Zhao, Yuqin Song, Huan Ren, Zhenyang Tian, Qi’an Liang, Yongxin Jin, Fang Bai, Zhihui Cheng, Jie Feng, Weihui Wu\u00a0<\/p>

Journal Name –\u00a0<\/strong>Microbiology Spectrum<\/p>

Citation\u00a0<\/b>\u00a0–\u00a0<\/strong>2022, 10(1), e02678-21\u00a0\u00a0<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Assessment of activity and resistance mechanisms to cefepime in combination with the novel \u03b2-lactamase inhibitors zidebactam, taniborbactam and enmetazobactam against a multicenter collection of carbapenemase-producing Enterobacterales<\/span><\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author<\/strong> – Juan Carlos V\u00e1zquez-Ucha, Cristina Lasarte-Monterrubio, Paula Guijarro-S\u00e1nchez , Marina Ovia\u00f1o, Laura \u00c1lvarez-Fraga, Isaac Alonso-Garc\u00eda, Jorge Arca-Su\u00e1rez, German Bou Alejandro Beceiro<\/p>

Journal Name –\u00a0<\/strong>Antimicrobial Agents and Chemotherapy<\/p>

Citation\u00a0<\/b>\u00a0–\u00a0<\/strong>AAC Accepted AAC.01676-21<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Antimicrobial Activity of Aztreonam in Combination with Old and New -Lactamase Inhibitors against MBL and ESBL Co-Producing Gram-Negative Clinical Isolates: Possible ptions for the Treatment of Complicated Infections<\/span><\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author<\/strong> – Gianluca Morroni, Raffaela Bressan, Simona Fioriti, Gloria D\u2019Achille, Marina Mingoia, Oscar Cirioni, Stefano Di Bella, Aurora Piazza, Francesco Comandatore, Carola Mauri, oberta Migliavacca, Francesco Luzzaro, Luigi Principe, Cristina Lagatolla<\/p>

Journal Name –\u00a0<\/strong>Antibiotics<\/p>

Citation\u00a0<\/b>\u00a0–<\/strong>2021, 10(11), 1341<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Activity of \u03b2-lactam plus \u03b2-lactam-enhancer combination cefepime\/zidebactam against Klebsiella pneumoniae harbouring defective OmpK35\/36 porins and arbapenemases<\/span><\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author<\/strong> – Prashant Joshi, Rahul Shrivastava, Sachin Bhagwat, Mahesh Patel<\/p>

Journal Name –\u00a0<\/strong>Diagnostic Microbiology and Infectious Disease<\/p>

Citation\u00a0<\/b>\u00a0–<\/strong>2021, 101(2), 115481<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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In vitro activity of cefiderocol, cefepime\/zidebactam, cefepime\/enmetazobactam, omadacycline, eravacycline, and other comparative agents against carbapenem-nonsusceptible Enterobacterales: Results from the Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART) in 2017\u20132020<\/span><\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author<\/strong> – Yu-Lin Lee, Wen-Chien Ko, Wen-Sen Lee, Po-Liang Lu, Yen-Hsu Chen, Shu-Hsing Cheng, Min-Chi Lu, Chi-Ying Lin, Ting-Shu Wu, Muh-Yong Yen, Lih-Shinn Wang, Chang-Pan Liu, Pei-Lan Shao, Zhi-Yuan Shi, Yao-Shen Chen, Fu-Der Wang, Shu-Hui Tseng, Chao-Nan Lin, Yu-Hui Chen, Wang-Huei Sheng, Chun-Ming Lee, Hung-JenTang, Po-Ren Hsueh<\/p>

Journal Name –\u00a0<\/strong>International Journal of Antimicrobial Agents<\/p>

Citation\u00a0<\/b>\u00a0–<\/strong>2021, 58(3), 106377<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Comment on: An update on cefepime and its future role in combination with novel \u03b2-lactamase inhibitors for MDR Enterobacterales and Pseudomonas aeruginosa<\/span><\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author<\/strong> – Nicolau David, Bhagwat Sachin, Abdelraouf Kamilia<\/p>

Journal Name –\u00a0<\/strong>Journal of Antimicrobial Chemotherapy<\/p>

Citation\u00a0<\/b>\u00a0–<\/strong>2021, 76(12), 3326\u20133327<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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In vitro evolution of cefepime\/zidebactam (WCK 5222) resistance in Pseudomonas aeruginosa: dynamics, mechanisms, fitness trade-off and impact on in vivo efficacy<\/span><\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong>Barcel\u00f3 Isabel; Cabot Gabriel; Palwe Snehal; Joshi Prashant; Takalkar Swapna; Periasamy Hariharan; Cortes-Lara Sara; Zamorano Laura; Sanchez-Diener Irina; Moya Bartolome; Bhagwat Sachin; Patel Mahesh; Oliver Antonio<\/p>

Journal Name –\u00a0<\/strong>Journal of Antimicrobial Chemotherapy<\/p>

Citation – <\/strong>JAC-2021-dkab213<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Comparative in vivo activity of human-simulated plasma and epithelial lining fluid exposures of WCK 5222 (cefepime\/zidebactam) against KPC- and OXA-48-like-producing Klebsiella pneumoniae in the neutropenic murine pneumonia model<\/span><\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong>Maxwell J Lasko, Kamilia Abdelraouf, David P Nicolau<\/p>

Journal Name –\u00a0<\/strong>Journal of Antimicrobial Chemotherapy<\/p>

Citation\u00a0– <\/strong>2021, 76(9) 2310\u20132316<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Activity of cefepime\/zidebactam (WCK 5222) against \u2018problem\u2019 antibiotic-resistant Gram-negative bacteria sent to a national reference laboratory<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong>Shazad Mushtaq, Paolo Garello, Anna Vickers, Neil Woodford, David M Livermore<\/p>

Journal Name –\u00a0<\/strong>Journal of Antimicrobial Chemotherapy<\/p>

Citation\u00a0– <\/strong>2021, 76(6), 1511\u20131522<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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In vitro activity of imipenem\/relebactam, meropenem\/vaborbactam, ceftazidime\/avibactam, cefepime\/zidebactam and other novel antibiotics against imipenem-non-susceptible Gram-negative bacilli from Taiwan<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong>Shu-Chen Kuo, Yung-Chih Wang, Mei-Chen Tan, Wei-Cheng Huang, Yih-Ru Shiau, Hui-Ying Wang, Jui-Fen Lai, I-Wen Huang and Tsai-Ling Lauderdale<\/p>

Journal Name –\u00a0<\/strong>Journal of Antimicrobial Chemotherapy<\/p>

Citation\u00a0– <\/strong>2021, dkab141, (Ahead of Print)<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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In vitro activity of cefepime\/zidebactam (WCK 5222) against recent Gram-negative isolates collected from high resistance settings of Greek hospitals<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author –\u00a0<\/strong>Sachin S Bhagwat, Nicholas J Legakis, Tilemachos Skalidis, Anastassios loannidis, Christos Goumenopoulos, Prashant R Joshi, Rahul Shrivasta<\/p>

Journal Name –\u00a0<\/strong>Diagnostic Microbiology and Infectious Disease<\/p>

Citation\u00a0– <\/strong>2021, 100(3), 115327<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Structural characterization of diazabicyclooctane b-Lactam \"Enhancers\" in complex with penicillin-binding proteins PBP2 and PBP3 of Pseudomonas aeruginosa<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong>Rajavel Malligarjunan, Kumar Vijay, Nguyen Ha, Wyatt Jacob, Marshall Steven H, Papp-Wallace Krisztina M, Deshpande Prasad, Bhavsar Satish, Yeole Ravindra, Bhagwat Sachin, Mahesh Patel, Robert A Bonomo, Focco van den Akker<\/p>

Journal Name –\u00a0<\/strong>mBio<\/p>

Citation\u00a0– <\/strong>2021, 12(1), e03058-20\u00a0<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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In Vitro Activity of WCK 5222 (Cefepime-Zidebactam) against Worldwide Collected Gram-Negative Bacilli Not Susceptible to Carbapenems<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong>Karlowsky James A, Hackel Meredith A, Bouchillon Samuel K, Sahm Daniel F<\/p>

Journal Name –\u00a0<\/strong>Antimicrobial Agents and Chemotherapy<\/p>

Citation\u00a0– <\/strong>2020, 64(12), e01432-20<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Activity of cefepime\/zidebactam against MDR Escherichia coli isolates harbouring a novel mechanism of resistance based on four-amino-acid inserts in PBP3<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong>Sachin S Bhagwat, Periasamy Hariharan, Prashant R Joshi, Snehal R Palwe, Rahul Shrivastava, Mahesh V Patel<\/p>

Journal Name –\u00a0<\/strong>Journal of Antimicrobial Chemotherapy<\/p>

Citation\u00a0– <\/strong>2020, 75(12), 3563-3567<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Effective inhibition of PBPs by cefepime and zidebactam in the presence of VIM-1 drives potent bactericidal activity against MBL-expressing Pseudomonas aeruginosa<\/span><\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong>Bartolome Moya, Sachin Bhagwat, Gabriel Cabot, German Bou, Mahesh Patel, Antonio Oliver<\/p>

Journal Name –\u00a0<\/strong>Journal of Antimicrobial Chemotherapy<\/p>

Citation\u00a0– <\/strong>2020, 75(6), 1474-1478<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Evaluation of the in vitro activity of WCK 5222 (cefepime\/zidebactam) and currently available combination therapies against single- and double-carbapenemase producing Enterobacteriaceae: Expanding the zone of hope<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong>Avery Lindsay M, Mullane Elias M, Nicolau David P<\/p>

Journal Name –\u00a0<\/strong>International Journal of Antimicrobial Agents<\/p>

Citation\u00a0– <\/strong>2020, 55(2), 105863\u00a0<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Comparative evaluation of the in vitro activities of WCK 5222 (cefepime\/zidebactam) and combination antibiotic therapies against carbapenem-resistant Pseudomonas aeruginosa<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong>Elias M. Mullane, Lindsay M. Avery, David P. Nicolau<\/p>

Journal Name –\u00a0<\/strong>Antimicrobial Agents and Chemotherapy<\/p>

Citation\u00a0– <\/strong>2020, 64(3), e01669-19\u00a0<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Efficacy of human-simulated bronchopulmonary exposures of cefepime, zidebactam and the combination (WCK 5222) against MDR Pseudomonas aeruginosa in a neutropenic murine pneumonia model<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong>James M. Kidd, Kamilia Abdelraouf, David P. Nicolau<\/p>

Journal Name –\u00a0<\/strong>Journal of Antimicrobial Chemotherapy<\/p>

Citation\u00a0– <\/strong>2020, 75(1), 149\u2013155<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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WCK 5222 (Cefepime\/Zidebactam) Pharmacodynamic Target Analysis against Metallo-\u03b2-lactamase producing Enterobacteriaceae in the Neutropenic Mouse Pneumonia Model<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong>Alexander J. Lepak, Miao Zhao, David R. Andes<\/p>

Journal Name –\u00a0<\/strong>Antimicrobial Agents and Chemotherapy\u00a0\u00a0<\/p>

Citation\u00a0– <\/strong>2019, 63(12), 01648-19<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Activity of cefepime\/zidebactam (WCK 5222) against Enterobacteriaceae, pseudomonas aeruginosa and Acinetobacter baumannii endemic to New York city medical centres<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong>Zeb Khan, Alejandro Iregui, David Landman, John Quale<\/p>

Journal Name –\u00a0<\/strong>Journal of Antimicrobial Chemotherapy<\/p>

Citation\u00a0– <\/strong>2019, 74(10), 2938\u20132942\u00a0<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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In Vivo Efficacy of WCK 5222 (Cefepime-Zidebactam) against Multidrug-Resistant Pseudomonas aeruginosa in the Neutropenic Murine Thigh Infection Model<\/span><\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong>Marguerite L. Monogue, Jennifer Tabor-Rennie, Kamilia Abdelraouf, David P. Nicolau<\/p>

Journal Name –\u00a0<\/strong>Antimicrobial Agents and Chemotherapy<\/p>

Citation\u00a0– <\/strong>2019, 63(7), e00233-19\u00a0<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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In vitro and in vivo activity of \u03b2-lactams in combination with novel \u03b2-lactam enhancers, zidebactam and WCK 5153, against multidrug-resistant metallo-\u03b2-lactamase producing Klebsiella pneumoniae<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong>Bartolome Moya, Isabel Maria Barcel\u00f3, Gabriel Cabot, Gabriel Torrens, Snehal Palwe, Prashant Joshi, Kushal Umarkar, Swapna Takalkar, Hariharan Periasamy, Sachin Bhagwat, Mahesh V. Patel, Germ\u00e1n Bou, and Antonio Oliver<\/p>

Journal Name –\u00a0<\/strong>Antimicrobial Agents and Chemotherapy<\/p>

Citation\u00a0– <\/strong>2019, 63(5), e00128-19\u00a0<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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The Novel \u03b2-Lactam Enhancer Zidebactam Augments the In Vivo Pharmacodynamic Activity of Cefepime in a Neutropenic Mouse Lung Acinetobacter baumannii Infection Model<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong>Bhagwat S. S, Periasamy H, Takalkar S. S, Palwe S. R, Khande H. N, Patel M. V<\/p>

Journal Name –\u00a0<\/strong>Antimicrobial Agents and Chemotherapy<\/p>

Citation\u00a0– <\/strong>2019, 63(4), e02146-18\u00a0<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Activity of Cefepime-Zidebactam against Multidrug-Resistant (MDR) Gram-Negative Pathogens<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong>Thomson Kenneth S, Abdel Ghani Sameh, Snyder James W, Thomson Gina K, Abdel Ghani Sameh, Thomson Gina K<\/p>

Journal Name –\u00a0<\/strong>Antibiotics<\/p>

Citation\u00a0– <\/strong>2019, 8(1), 32\u00a0<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Single-Center Evaluation of the Pharmacokinetics of WCK 5222 (Cefepime-Zidebactam Combination) in Subjects with Renal Impairment<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong>Richard A Preston, Grigor Mamikonyan, Stephane DeGraff, James Chiou, Christopher J Kemper, Allan Xu, Mushtaque Mastim, Ravindra Yeole, Rajesh Chavan, Anasuya Patel, H David Friedland, Ashima Bhatia<\/p>

Journal Name –\u00a0<\/strong>Antimicrobial Agents and Chemotherapy<\/p>

Citation\u00a0– <\/strong>2019, 63(1), e01484-18\u00a0<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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In Vivo Efficacy of Humanized WCK 5222 (Cefepime-Zidebactam) Exposures against Carbapenem-Resistant Acinetobacter baumannii in the Neutropenic Thigh Model. S.S.Almarzoky Abuhussain<\/span><\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong>S.S.Almarzoky Abuhussain, Lindsay M. Avery, Kamilia Abdelraouf, David P. Nicolau<\/p>

Journal Name –\u00a0<\/strong>Antimicrobial Agents and Chemotherapy<\/p>

Citation\u00a0– <\/strong>2019, 63(1), e01931-18\u00a0<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Strategic Approaches to Overcome Resistance against Gram-Negative Pathogens Using \u03b2-Lactamase Inhibitors and \u03b2-Lactam Enhancers: Activity of Three Novel Diazabicyclooctanes WCK 5153, Zidebactam (WCK 5107), and WCK 4234<\/span><\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong>Papp-Wallace Krisztina M, Nguyen Nhu Q, Jacobs Michael R, Bethel Christopher R, Barnes Melissa D, Kumar Vijay, Bajaksouzian, Saralee, Rudin Susan D, Rather Philip N, Bhavsar Satish<\/p>

Journal Name –\u00a0<\/strong>Journal of Medicinal Chemistry<\/p>

Citation\u00a0– <\/strong>2018, 61(9), 4067-4086\u00a0<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Plasma and Intrapulmonary Concentrations of Cefepime and Zidebactam following Intravenous Administration of WCK 5222 to Healthy Adult Subjects<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong>Keith A Rodvold, Mark H Gotfried, Rakesh Chugh, Mugdha Gupta, Anasuya Patel, Rajesh Chavan, Ravindra Yeole, H David Friedland, Ashima Bhatia<\/p>

Journal Name –\u00a0<\/strong>Antimicrobial Agents and Chemotherapy<\/p>

Citation\u00a0– <\/strong>2018, 62(8), e00682-18\u00a0<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Simultaneous determination of zidebactam and cefepime in dog plasma by LC\u2013MS\/MS and its application to pre\u2010clinical pharmacokinetic study<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong>Kiran Patil, Harshad Tambe, Vineet Zope, Rajesh Chavan, Ravindra Yeole, Mahesh V. Patel<\/p>

Journal Name –\u00a0<\/strong>Biomedical Chromatography<\/p>

Citation\u00a0– <\/strong>2018, 32(8), e4249\u00a0<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Assessment of the In Vivo Efficacy of WCK 5222 (Cefepime-Zidebactam) against Carbapenem-ResistantAcinetobacter baumannii in the Neutropenic Murine Lung Infection Model<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong>Avery Lindsay M, Abdelraouf Kamilia, Nicolau David P, Nicolau David P<\/p>

Journal Name –\u00a0<\/strong>Antimicrobial Agents and Chemotherapy<\/p>

Citation\u00a0– <\/strong>2018, 62 (11), e00948-18\u00a0<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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WCK 5222 (Cefepime-Zidebactam) Antimicrobial Activity against Clinical Isolates of Gram-Negative Bacteria Collected Worldwide in 2015<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong>Helio S. Sader, Mariana Castanheira, Michael Huband, Ronald N. Jones, Robert K. Flamm<\/p>

Journal Name –\u00a0<\/strong>Antimicrobial Agents and Chemotherapy<\/p>

Citation\u00a0– <\/strong>2017, 61(5), e00072-17<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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WCK 5222 (cefepime\/zidebactam) antimicrobial activity tested against Gram-negative organisms producing clinically relevant \u03b2-lactamases<\/span><\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong>Helio S Sader, Paul R Rhomberg, Robert K Flamm, Ronald N Jones, Mariana Castanheira<\/p>

Journal Name –\u00a0<\/strong>Journal of Antimicrobial Chemotherapy<\/p>

Citation\u00a0– <\/strong>2017, 72(6), 1696-1703\u00a0<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Potent \u03b2-Lactam Enhancer Activity of Zidebactam and WCK 5153 against Acinetobacter baumannii, Including Carbapenemase-Producing Clinical Isolates<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong>Bartolome Moya, Isabel M. Barcelo, Sachin Bhagwat, Mahesh V. Patel, German Bou, Krisztina M. Papp-Wallace, Robert A. Bonomo Antonio Oliver<\/p>

Journal Name –\u00a0<\/strong>Antimicrobial Agents and Chemotherapy<\/p>

Citation\u00a0– <\/strong>2017, 61(11), e01238-17\u00a0<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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In vitro activity of cefepime\/zidebactam (WCK 5222) against Gram-negative bacteria<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong>Livermore DM, Mushtaq S, Warner M, Vickers A, Woodford N,<\/p>

Journal Name –\u00a0<\/strong>Journal of Antimicrobial Chemotherapy<\/p>

Citation\u00a0– <\/strong>2017, 72(5), 1373\u20131385\u00a0<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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WCK 5107 (Zidebactam) and WCK 5153 Are Novel Inhibitors of PBP2 Showing Potent \u201c\u03b2-Lactam Enhancer\u201d Activity against Pseudomonas aeruginosa, Including Multidrug-Resistant Metallo-\u03b2- Lactamase-Producing High-Risk Clones<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong>Moya Bartolome, Barcelo Isabel M, Oliver Antonio, Bhagwat Sachin, Patel Mahesh, Bou German, Papp-Wallace Krisztina M, Bonomo Robert A, Papp-Wallace Krisztina M, Bonomo Robert A<\/p>

Journal Name –\u00a0<\/strong>Antimicrobial Agents and Chemotherapy<\/p>

Citation\u00a0– <\/strong>2017, 61(6), e02529-16\u00a0<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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In vitro activity of cefepime\/zidebactam and cefepime\/taniborbactam against aztreonam\/avibactam-resistant NDM-like-producing Escherichia coli clinical isolates Author – Christophe Le Terrier , Patrice Nordmann, Mustafa Sadek, Laurent Poirel Journal Name –\u00a0Journal of Antimicrobial Chemotherapy Citation\u00a0\u00a0–\u00a02023 May; 78(5): 1191\u20131194 Read More Successful Use of Cefepime-Zidebactam (WCK 5222) as a Salvage Therapy for the Treatment of Disseminated Extensively Drug-Resistant … <\/p>\n

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