{"id":9577,"date":"2023-03-10T06:47:50","date_gmt":"2023-03-10T06:47:50","guid":{"rendered":"https:\/\/demo.wockhardt.com\/?page_id=9577"},"modified":"2023-05-20T11:17:13","modified_gmt":"2023-05-20T11:17:13","slug":"wck-4873","status":"publish","type":"page","link":"https:\/\/www.wockhardt.com\/about-us\/research-and-development\/new-drug-discovery\/publications\/wck-4873\/","title":{"rendered":"WCK 4873"},"content":{"rendered":"\t\t
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A facile one-pot, three-component protocol for, chiral synthesis of Cyanolactone as key intermediate of the Nafithromycin <\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong> Furqan Diwan, Amit Pund, Prathmesh Deshpande, Rajesh Pursani, Mohammad Rafeeq, Ram Prasad Yadav, Arvind Merwade<\/p>

Journal Name –\u00a0<\/strong>Research on Chemical Intermediates<\/p>

Citation – <\/strong>Under Review\u00a0<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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In Vitro Activity of Nafithromycin (WCK 4873) against Chlamydia pneumoniae<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong> Stephan Kohlhoff, Margaret R. Hammerschlag<\/p>\n

Journal Name – <\/strong>Antimicrobial Agents and Chemotherapy<\/p>\n

Impact Factor – <\/strong>4.45<\/p>\n

Citation – <\/strong>2021, 65(9), e00585-21<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Activity of novel lactone ketolide nafithromycin against multicentric invasive and non-invasive pneumococcal isolates collected in India <\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong> Balaji Veeraraghavan, Rosemol Varghese, Karnika Saigal, S Balasubramanian, P Sulochana Putli Bai, Binesh Lal Y, Ayyanraj Neeravi, Pavithra Baskar, Kavipriya Anandhan, C P Girish Kumar, Yuvraj Jayaraman, Vijaya Lakshmi Nag, Sujata Baveja, Bhavana J, Shrikrishna A Joshi, Ranganathan Iyer<\/p>

Journal Name –\u00a0<\/strong>JAC-Antimicrobial Resistance<\/p>

Citation – <\/strong>2021, 3(2), dlab066\u00a0<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Preclinical safety evaluation of nafithromycin (WCK 4873) with emphasis on liver safety in rat and dog<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong> Nandanwar, Manohar; Chavan, Rajesh; Kansagara, Atul; Patel, Muftedar Ahmed; Patel, Anasuya; Yeole, Ravindra; Patel, Mahesh<\/p>

Journal Name –\u00a0<\/strong>Regulatory Toxicology and Pharmacology<\/p>

Impact Factor – <\/strong>2.89<\/p>

Citation – <\/strong>2021, 122, 104889\u00a0<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Assessment of the in vitro cytochrome P450 (CYP) inhibition potential of Nafithromycin, a next generation lactone ketolide antibiotic<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong> Rajesh P. Chavan , Vineet S. Zope , Nilesh N. Chavan , Kiran Patil , Ravindra D. Yeole , Sachin B. Bhagwat & Mahesh V. Patel<\/p>

Journal Name –\u00a0<\/strong>Xenobiotica<\/p>

Impact Factor – <\/strong>1.902<\/p>

Citation – <\/strong>2021, 51(3), 251-261\u00a0<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Pre-treatment of nafithromycin attenuates inflammatory response in murine lipopolysaccharide induced acute lung injury<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong> Trivedi Jinal, Shaikh Javeed, Chavan Nilesh, Thorve Deepak, Chaudhary Bhushan, Karade Avinash, Gupta Sangita, Patel Anasuya, Bhagwat Sachin<\/p>

Journal Name –\u00a0<\/strong>Journal of Cytokine<\/p>

Impact Factor – <\/strong>2.952<\/p>

Citation – <\/strong>2020, 129, 155049\u00a0<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Safety, Tolerability, and Pharmacokinetics of Oral Nafithromycin (WCK 4873) after Single or Multiple Doses and Effects of Food on Single-Dose Bioavailability in Healthy Adult Subjects<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong> Piotr Iwanowski, Ashima Bhatia, Mugdha Gupta, Anasuya Patel, Rajesh Chavan, Ravindra Yeole, David Friedland<\/p>

Journal Name –\u00a0<\/strong>Antimicrobial Agents and Chemotherapy<\/p>

Impact Factor – <\/strong>4.921<\/p>

Citation – <\/strong>2019, 63(12), e01253-19\u00a0<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Identification and Quantification of Related Impurities of a Novel Ketolide Antibiotic Nafithromycin<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong> V. Ahirrao, V. Rane, K. Patil, Rajiv A. Jadhav, V. Shinde, V. V. Deshmukh, Sanjay K. Dabhade, R. Kale, S. K. Gupta, R. D. Yeole<\/p>

Journal Name –\u00a0<\/strong>Chromatographia<\/p>

Impact Factor – <\/strong>1.596<\/p>

Citation – <\/strong>2019, 82(7),1059\u20131068\u00a0<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Enantiomeric Separation and Thermodynamic investigation of (R)-5-[1-(4-Nitrobenzylsulfonyloxy)-ethyl]-5-(pyridine-2-yl)- [1,3,4]-thiadiazole, a Key Intermediate of Nafithromycin<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong> Rane Vipul P, Ahirrao Vinod K, Patil Kiran R, Jadhav Rajiv A, Ingle Rahul G, More Kiran B, Yeole Ravindra D<\/p>

Journal Name –\u00a0<\/strong>Analytical Chemistry Letters<\/p>

Impact Factor – <\/strong>1.727<\/p>

Citation – <\/strong>2019, 9(5), 625-633\u00a0<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Simultaneous determination of novel ketolide antibiotic nafithromycin and its major metabolite in human plasma using liquid chromatography tandem mass spectrometry<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong> Patil Kiran R, Yeole Ravindra D, de Zwart Marcel, Pruim Peter<\/p>

Journal Name –\u00a0<\/strong>Bioanalysis<\/p>

Impact Factor – <\/strong>2.371<\/p>

Citation – <\/strong>2019, 11(19), 1767-1776\u00a0<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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In Vitro Activity of the Novel Lactone Ketolide Nafithromycin (WCK 4873) When Tested against Contemporary Clinical Bacteria from a Global Surveillance Program<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong> R. K. Flamm, P. R. Rhomberg, H. S. Sader<\/p>

Journal Name –\u00a0<\/strong>Antimicrobial Agents and Chemotherapy<\/p>

Impact Factor – <\/strong>4.548<\/p>

Citation – <\/strong>2017, 61(12), e01230-17\u00a0<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Determination of Disk Diffusion and MIC Quality Control Ranges for Nafithromycin (WCK 4873), a New Lactone-Ketolide<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong>Hackel Meredith A, Karlowsky James A, Dressel Dana, Daniel F<\/p>

Journal Name –\u00a0<\/strong>Journal of Clinical Microbiology<\/p>

Impact Factor – <\/strong>4.054<\/p>

Citation – <\/strong>2017, 55(10), 3021-3027\u00a0<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Comparison of Plasma and Intrapulmonary Concentrations of Nafithromycin (WCK 4873) in Healthy Adult Subjects<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Author – <\/strong>Rodvold, Keith A, Gotfried Mark H, Chugh Rakesh, Gupta Mugdha, David Friedland H, Bhatia Ashima\u00a0<\/p>

Journal Name –\u00a0<\/strong>Antimicrobial Agents and Chemotherapy<\/p>

Impact Factor – <\/strong>4.548<\/p>

Citation – <\/strong>2017, 61(9), e01096-17<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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A facile one-pot, three-component protocol for, chiral synthesis of Cyanolactone as key intermediate of the Nafithromycin Author – Furqan Diwan, Amit Pund, Prathmesh Deshpande, Rajesh Pursani, Mohammad Rafeeq, Ram Prasad Yadav, Arvind Merwade Journal Name –\u00a0Research on Chemical Intermediates Citation – Under Review\u00a0 Read More In Vitro Activity of Nafithromycin (WCK 4873) against Chlamydia pneumoniae … <\/p>\n

Continue reading “WCK 4873”<\/span><\/a><\/p>\n","protected":false},"author":4,"featured_media":0,"parent":9547,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"yoast_head":"\nWCK 4873 - Wockhardt<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.wockhardt.com\/about-us\/research-and-development\/new-drug-discovery\/publications\/wck-4873\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"WCK 4873 - Wockhardt\" \/>\n<meta property=\"og:description\" content=\"A facile one-pot, three-component protocol for, chiral synthesis of Cyanolactone as key intermediate of the Nafithromycin Author – Furqan Diwan, Amit Pund, Prathmesh Deshpande, Rajesh Pursani, Mohammad Rafeeq, Ram Prasad Yadav, Arvind Merwade Journal Name –\u00a0Research on Chemical Intermediates Citation – Under Review\u00a0 Read More In Vitro Activity of Nafithromycin (WCK 4873) against Chlamydia pneumoniae … Continue reading "WCK 4873"\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.wockhardt.com\/about-us\/research-and-development\/new-drug-discovery\/publications\/wck-4873\/\" \/>\n<meta property=\"og:site_name\" content=\"Wockhardt\" \/>\n<meta property=\"article:modified_time\" content=\"2023-05-20T11:17:13+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/demo.wockhardt.com\/wp-content\/uploads\/2023\/03\/01_Research-on-Chemical-Intermediates.jpg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.wockhardt.com\/about-us\/research-and-development\/new-drug-discovery\/publications\/wck-4873\/\",\"url\":\"https:\/\/www.wockhardt.com\/about-us\/research-and-development\/new-drug-discovery\/publications\/wck-4873\/\",\"name\":\"WCK 4873 - 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